Lihlahisoa
2,6-Di-tert-butyl-4-methylpyridine
Foromo ea Sebopeho
Ponahalo: kristale e tšoeu ea acicular
Boima: 1,476 g/cm3
Sebaka se qhibilihang: 31-32 ℃
Sebaka se belang: 148-153 ℃ (12.6kPa)
Lenane la refractive: N20 /D 1.4763(lit.)
Sebaka se benyang: 183 °F
Maemo a polokelo: 2-8°C
Acidity coefficient (pKa): 6.88±0.10(E boletsoeng esale pele)
Lintlha tsa Polokeho
Ke tsa thepa e akaretsang
Khoutu ea meetlo: 2942000000
Sekhahla sa phokotso ea lekhetho la kantle ho naha (%) : 13%
Kopo
Organic synthetic intermediate, setsi se thibetsoeng ka thata, se seng sa nucleophilic se khethollang pakeng tsa Brnsted (protonic) le Lewis acids.E nolofalletsa phetoho e tobileng ea lihlahisoa tse phahameng tsa aldehydes1 le ketones1,2 ho li-vinyl triflates.
2,6-Di-tert-butyl-4-methylpyridine ke motsoako oa manyolo o nang le foromo ea molek'hule C14H23N, karolo ea bohlokoa ea lipakeng tsa motsoako oa manyolo, haholo-holo o sebelisoang ho li-intermediates tsa meriana, motsoako oa manyolo, li-solvents, le tsona li ka sebelisoa tlhahiso ea dae, chefo e bolaeang likokoanyana. tlhahiso le monko o monate, joalo-joalo.
Mokhoa oa tlhahiso
1. Etsa 2,6 di-tert-butyl-4-methylbenzyl trifluoromethanesulfonate Ka botlolong ea 100-mL e tharo e nang le tube ea kenyelletso ea naetrojene, mochine o tsitsitseng oa khatello, motlakase oa motlakase le leqhoa le nang le leqhoa le nang le tube e omeletseng, eketsa 24.2 g (0.2 mol) ea trimethylethyl phthalide chloride le 3.7 g (0.05 mol) ea tert-butanol.Motsoako oa karabelo o ile oa futhumatsoa ka bateng ea oli ho ea ho 85 ° C.Joale 15 g (0.1 mol) ea trifluoromethanesulfonic acid e ile ea eketsoa ka metsotso e fetang 15.Boitšoaro bo ile ba tsoela pele ka metsotso ea 10, 'me sehlahisoa sa karabelo se sootho se bobebe se ne se pholile ka bateng ea leqhoa' me se tšeloa ka 100 ml ea ether e batang.Pula e sootho e ile ea tlhotloa le ho omisoa ho fumana 9.6 g (54%) ea letsoai la buzz le liehileng.(Ha ho tlhoekiso e hlokahalang: bakeng sa mohato o latelang oa ho lokisa, tsosolosa habeli ho tloha ho chloroform ho ea ho carbon tetrachloride 3: 1) ho likristale tse se nang mebala tse kang nale.
2. Ho lokisoa ha 2,6-Di-tert-butyl-4-methyl-vizine Tlas'a ho sisinyeha, ho emisoa ha 10 g (0.028 mol) ea letsoai le tala la vizine ka 200 mL ea 95% ea ethanol e pholileng ho 60 ° C e ne e le. e kenyellelitsoe hang ho 100 mL ea ammonia e teteaneng e hatselitsoeng ho 60°C ka botlolong ea lithara e le 1 serapeng-tlase.Boitšoaro bo ile ba tsoela pele ho 60 ° C ka metsotso e 30 le 40 ° C bakeng sa lihora tsa 2, nakong eo ho emisoa ho ileng ha qhaloa.Joale, motsoako oa karabelo o ile oa tšeloa ka 500 ml ea 2% ea tharollo ea sodium hydroxide e futhumala butle ho mocheso oa kamore.E ntšitsoe ka .4-100 ml ea pentane, li-extracts tse kopantsoeng, 25 ml ea tharollo e tletseng sodium chloride e hlatsoitsoeng, 100 ml ea mahloriso a pentane rotary evaporator.
