Lihlahisoa
5-Fluorocytosine
Foromo ea Sebopeho
Ea nama
Ponahalo: Phofo e tšoeu
Boima: 1.3990 (khakanyo)
Sebaka se qhibilihang: 298-300 °C (Dec.) (lit.)
Ntho e belang.
Refractivity
Flash point.
Lintlha tsa Polokeho
Sehlopha se kotsi.
Nomoro ea Lipalangoang tsa Thepa e Kotsi.
Sehlopha sa ho paka.
Kopo
Flucytosine ka molomo e sebelisetsoa ho phekola mafu a tebileng a bakoang ke mefuta e hlaselehang habonolo ea Candida kapa Cryptococcus neoformans.E ka boela ea sebelisoa bakeng sa phekolo ea chromomycosis (chromoblastomycosis), haeba mefuta e hlaselehang habonolo e baka tšoaetso.Flucytosine ha ea lokela ho sebelisoa e le ntho e le 'ngoe feela ea tšoaetso ea fungal e behang bophelo kotsing ka lebaka la liphello tse fokolang tsa antifungal le tsoelo-pele e potlakileng ea ho hanyetsa, empa ho e-na le hoo e kopantsoe le amphotericin B le/kapa li-antifungals tsa azole tse kang fluconazole kapa itraconazole.Mafu a manyane a kang candidal cystitis a ka phekoloa ka flucytosine feela.Linaheng tse ling, phekolo e nang le butle-butle infusions intravenous bakeng sa nako e fetang beke le eona ke khetho ea phekolo, haholo-holo haeba lefu lena le beha bophelo kotsing.
Tšoaetso e tebileng ea fungal e ka 'na ea hlaha ho ba nang le immunocompromised.Batho bana ba rua molemo kalafong e kopaneng ho kenyeletsoa flucytosine, empa liketsahalo tsa litla-morao tsa kalafo e kopaneng, haholo-holo ka amphotericin B, li ka ba holimo.
5-Fluorocytosine e sebelisoa ho phekola mafu a fungal a bakoang ke Cryptococcus le Candida, joalo ka fungal sepsis, endocarditis, meningitis, le li-antifungal agents bakeng sa tšoaetso ea matšoafo le moroto.
Sebopeho
Sehlahisoa sena se na le ts'ebetso e phahameng ea antifungal khahlano le Candida spp.le Candida spp.hape e na le ts'ebetso ea antibacterial khahlano le Bacillus spp.le Mycobacterium spp.Sehlahisoa se na le likokoana-hloko tse fokolang haholo le fungicidal maemong a phahameng.Mokhoa oa ts'ebetso ke ho thibela tlhahiso ea fungal nucleic acid.Ho bonolo ho hlahisa fungus ho hanyetsa sehlahisoa sena.
Mehato ya tlhokomelo
E kopantsoe le amphotericin B, e na le phello ea synergistic, empa e ka fokotsa ho ntšoa ha sehlahisoa sena ho tsoa liphio le ho eketsa khatello ea mali, e ka bakang ts'ebetso e chefo tsamaisong ea liphio le mali.Ka hona, tlhōrō ea mali e lokela ho hlahlojoa le ho bolokoa ho 50-75μg / ml, e sa feteng 100μg / ml;tšebeliso ea li-inhibitors tsa masapo a masapo a ka 'na a eketsa chefo ea hematologic ea sehlahisoa sena.
Sehlahisoa sena se ka baka ① ho nyekeloa ke pelo, letšollo, lekhopho, joalo-joalo;② ts'enyo ea sebete, matšoao a ts'ebetso ea sebete haholo, empa hape le hepatomegaly kapa hepatic necrosis;③ myelosuppression leukocyte le phokotso ea liplatelete, ka linako tse ling e ka baka cytopenia ea mali kaofela.Khaello e bolaeang ea granulocytic leukocyte le phokolo ea mali ea pholiso le eona e tlalehiloe;④ lipono, hlooho le vertigo le tsona li tlalehiloe.Ka hona, sebelisa ka hloko ho bakuli ba nang le ts'oaetso ea sebete kapa ea renal, mathata a mali le khatello ea masapo.Setšoantšo sa mali sa peripheral, sebete le liphio le ts'ebetso ea moroto li lokela ho hlahlojoa khafetsa ha u sebelisa sehlahisoa sena.E na le phello ea teratogenic litekong tsa liphoofolo, 'me e lokela ho sebelisoa ka hloko ho bakhachane.
Litlamorao tse mpe li kenyelletsa ho phahama ha transaminase, alkaline phosphatase, matšoao a ka mpeng, leukopenia, phokolo ea mali, thrombocytopenia, ho senyeha ha renal, hlooho e opang, ho fokotseha ha pono, lipono, tahlehelo ea kutlo, dyskinesia, phokotseho ea serum potasiamo, calcium le phosphorous, mohlala, rash. .
