Bucladesine

Tlhaloso e Khutšoanyane:

Lebitso: Bucladesine
Lebitso la lebitso: N-6, O-2'-Dibutyryl adenosine cyclic 3′: 5'-monophosphate;N-(9-beta-D-Ribofuranosyl-9H-furin-6-yl)-butyramide cyclic 3′,5′-(hydrogen phosphate) 2′-butyrate
Nomoro ea CAS: 16980-89-5
Nomoro ea ho kena ea EINECS: 241-059-4
Foromo ea molek'hule: C18H23N5NaO8P
Boima ba molek'hule: 491.37

Re romelle lengolo-tsoibila

Lintlha tsa Sehlahisoa

Li-tag tsa Sehlahisoa

Foromo ea Sebopeho

Lintho Tsa 'Mele
Ponahalo: Sehlahisoa se sesoeu se tiileng
Boemo ba polokelo: -20°C
Sollubility H2O: 50 mg/mL

Lintlha tsa Polokeho
Ke ea thepa e tloaelehileng

Kopo
Dibutyryl cyclic adenosine monophosphate sodium ke e nkiloeng ho cyclic adenosine monophosphate, e sebelisetsoang ho phekola lefu la pelo le ho hloleha ha pelo.Ka 1999, oli ea sodium ea Dibutyryl cyclic adenosine monophosphate e ile ea etsoa ho phekola tšoaetso ea letlalo le seso sa letlalo.

Ho lokisoa ha sodium dibutyryl cyclophosphate adenosine: Ka har'a botlolo e nang le cyclophosphate adenosine butle-butle eketsa aqueous sodium hydroxide solution (3 mol/L) dropwise, mocheso o laoloang, ho theoha ho qeta ho futhumala ho mocheso oa kamore, fetola pH ho 7 ~ 8 ka tharollo ea HCl. 20%), eketsa pula ea anhydrous ethanol ea 'mala o mosoeu o tiileng, o hloekisang, o omisang ho fumana letsoai le tiileng la sodium;letsoai la sodium le anhydride ea n-butyl tlas'a tšireletso ea mocheso oa N2 ho 140 ℃ karabelo.Tlhokomelo ea TLC, karabelo e felile ebe e theoleloa mocheso oa kamore, butle-butle eketsa methyl tert-butyl ether, ts'ebetso ea ts'usumetso e matla, Chemicalbook ho fumana sehlahisoa se batlang se le tšoeu se tiileng.Motsoako oa methyl tert-butyl ether le acetone o ile oa emisoa hape ho fumana sehlahisoa se lebisitsoeng sa phofshoana e tšoeu.Biological activityDibutyryl-cAMP(Bucladesine,dbcAMP) ke PKA activator e kenang ka selefounung e sebetsang ka ho etsisa endogenous cAMP.Dibutyryl-cAMP(Bucladesine) hape ke phosphodiesterase(PDE) inhibitor.
Lithuto tsa in vitro: Dibutyryl-cAMP e thibela ho kenngoa ha tsoekere ea neuronal ka ts'ebetso ea PKA.Ho li-hepatocyte tsa rat, Dibutyryl-cAMP e thibela polelo ea inducible nitric oxide synthase le ts'ebetso e tlamang ea NF-kappaB.dibutyrChemicalbookyl-cAMP e boetse e thibela TNFalpha-induced rod cell apoptosis ka ho thibela FADD upregulation.
Lithuto tsa in vivo: Moetsong oa toeba, Bucladesine (600nM/ mouse, ip) e fetotse zinc chloride le lead acetate e bakileng ho se holehe ho boloka mohopolo.

E fetileng: China Diphenylacetonitrile Manufacture Supplier

E 'ngoe: 4,4'-Bis ( dimethylamino ) Thiobenzophenone