Lihlahisoa
Polyinosinic Acid-polycytidylic Acid
Foromo ea Sebopeho
Ea nama
Ponahalo: phofo e tshweu kapa e sa tshweu
Botenya.
Sebaka se qhibilihang.
Ntho e belang.
Refractivity
Flash point.
Lintlha tsa Polokeho
Sehlopha se kotsi.
Nomoro ea Lipalangoang tsa Thepa e Kotsi.
Sehlopha sa ho paka.
Kopo
Poly I: C e tsejoa e sebelisana le toll-like receptor 3 (TLR3), e hlahisoang lera la endosomal la B-cell, macrophages le dendritic cell.Poly I:C e na le sebopeho se ts'oanang le RNA e nang le likhoele tse peli, e teng ho livaerase tse ling 'me ke "tlhaho" e susumetsang ea TLR3.Kahoo, Poly I: C e ka nkuoa e le analoge ea maiketsetso ea RNA e nang le likhoele tse peli mme ke sesebelisoa se tloaelehileng sa lipatlisiso tsa mahlale mabapi le sesole sa 'mele.
Sebopeho
Sehlahisoa sena ke "interferon inducer" ea maiketsetso, e leng polyribonucleotide e nang le mahlakore a mabeli e entsoeng ka polyinosinic acid le polycytidylic acid.Kaha interferon e itšetlehile ka mefuta-futa, ho thata ho lokisetsa palo e kholo bakeng sa ts'ebeliso ea meriana, kahoo hangata e sebelisoa e le sekontiri sa interferon ho kenya interferon.Ntle le moo, asiti ea polyinosinic e ntse e na le karolo ea adjuvant ea 'mele ea ho itšireletsa mafung, e ka tsosang sistimi ea reticuloendothelial, ea ntlafatsa ts'ebetso ea phagocytic ea phagocyte, ea ntlafatsa sebopeho sa li-antibodies, e susumetsa karabelo ea allograft le ho lieha ho arabela.E na le litlamorao tse fapaneng tsa antiviral le antitumor.
Lisebelisoa le mekhoa ea ho kopanya
Kakaretso
Polycytidylic acid, eo hape e tsejoang e le polyinosinic acid, polyhypoxanthine nucleotide le polycytidine nucleotide, ke e 'ngoe ea polynucleotides, e nang le ketane e habeli ea polynucleotide ea polyinosinic acid le polycytidylic acid, e nang le sebopeho sa decolorization le ntlha e qhibilihang, le 20 ℃. .
Liphello tsa Pharmacological
1. Polyinosinic acid e na le ts'ebetso e ntle ea ts'ebetso ea ts'ireletso ea 'mele e khethehileng le e seng e tobileng.
(1) Li-polymyocyte li ntlafatsa tšebetso ea lisele tsa 'mele
(2) Li-polymyocyte li khothalletsa ho hlahisa li-cytokine tse sa tšoaneng
(3) Ho kenngoa ha protheine ea Mx ka polymyocyte
(4) Li-polymyocyte li khothalletsa tlhahiso ea li-antibodies ho vivo
2. Tšusumetso e khahlanong le kokoana-hloko ea polymyocyte
Liteko tsa in vitro, liteko tsa liphoofolo le liteko tsa meriana ea batho li pakile hore polymyxins e na le mefuta e mengata ea litlamorao tse thibelang kokoana-hloko, ho kenyelletsa kokoana-hloko ea yellow fever, kokoana-hloko ea encephalomyelitis, kokoana-hloko ea feberu ea Rift Valley, kokoana-hloko ea avian influenza, kokoana-hloko ea lefu la sebete, kokoana-hloko ea AIDS, leoto le molomo. kokoana-hloko ea mafu, kokoana-hloko ea conjunctivitis, kokoana-hloko e bonolo, kokoana-hloko ea Mengo, kokoana-hloko ea pox, kokoana-hloko ea myocarditis, kokoana-hloko ea Aleutian, coxsackievirus, joalo-joalo Ho 'nile ha pakoa hore phello ea thibelo ea Polymyxa e molemo ho feta phello ea phekolo ea tšoaetso ea kokoana-hloko.
Kopo
1.Homopolymer e nang le mahlakore a mabeli e ka sebelisoang e le mohlala oa RNA ho ithuta pontšo ea lisele boemong ba TLR3 ho lemoha RNA e nang le mefuta e 'meli, eo hape e leng eona phello e ka sehloohong ea karabelo ea 'mele ea ho itšireletsa mafung ho likokoana-hloko tsa kokoana-hloko.
2.E kopantsoe le asiti ea polyinosinic ho theha sele ea polyinosinic, e sebelisetsoang ho phekola lefu la sebete la kokoana-hloko, herpes zoster, herpes simplex keratitis, herpes stomatitis, seoa sa feberu ea mali, joalo-joalo.
3. E na le phello ea 'mele ea ho itšireletsa mafung, e susumetsa tsamaiso ea reticuloendothelial, e ntlafatsa phagocytosis, e ntlafatsa sebōpeho sa li-antibody, e susumetsa maikutlo a allograft le ho lieha ho itšoara.E na le phello e pharaletseng ea antiviral le phello ea antitumor.Haholo-holo e sebelisoang tleliniking bakeng sa: thibelo kapa kalafo ea tšoaetso ea kokoana-hloko, phekolo ea herpes zoster, herpetic keratitis, kokoana-hloko hepatitis.Kalafo e thusang ea lihlahala.Litlamorao tse mpe haholo li kenyelletsa hypothermia ea nakoana le maemo a motho ka mong a feberu e phahameng ho feta 38℃, eo hangata e kokobelang ka bo eona matsatsing a 1-2.Haeba feberu e sa fokotsehe matsatsing a 2, moriana o lokela ho emisoa hang-hang.Bofokoli, molomo o omeletseng, ho tsekela, ho nyekeloa ke pelo, joalo-joalo le tsona lia bonoa.
