Lihlahisoa
3,3'- diindolylmethane
Tlhaloso
3,3'-diindolylmethane ke setsi sa meriana;E ka fumanoa lihlahisoa tsa tlhaho tsa phytochemicals tsa Cruciferae Plants, acid catalyzed reaction products, indole-3-methanol;E na le mosebetsi oa anti-tumor agent;Tlas'a boemo ba mahloriso batlang e phahameng, derivative ke ke feela ka ho toba potlakisa apoptosis ea lisele tsa mofetše oa motho, empa hape sensitize tselana ho susumelletsa apoptosis ea lisele tsa mofetše oa motho;Chemicalbookdim e etsa hore ho be le thibelo ea lisele tsa G1 liseleng tsa kankere ea matsoele ea MCF-7 ka mochine le polelo ea kenyelletso;Dim ke inhibitor e matla ea mitochondrial h + -atpase;Joalo ka motšehetsi e mocha oa kholo ea semela, dim le tse tsoang ho eona li sebelisitsoe lipatlisisong tsa sistimi e sebetsang hantle.
Lintlha tsa Sehlahisoa
Cas No.: 1968-05-4
Bohloeki: ≥98%
Setšoantšo sa C17H14N2
Foromo ea Wt.Tlhaloso: 246.31
Lebitso la lik'hemik'hale: 3,3'-Diindolylmethane
Synonym : :3,3'-Diindolylmethane(DIM);Di(1H-indol-3-yl);Semela:Indole;3,3'-DIINDOLYLMETHANE,>=98%(HPLC);3,3'-METHYLENEBIS- 1H-INDOLE;3,3'-METHYLENEBISINDOLE;3,3'-METHYLENEDIINDOLE;3,3'-DIINDOLYLMETHANE
Sebaka sa ho qhibiliha: 167 °C
Sebaka se belang: 230 °C
Solubility: Chloroform (Hanyenyane), Methanol (Hanyenyane)
Ponahalo: Phofo e tsoeu
Thomello le Polokelo
Botsitso ba polokelo Mocheso o khothaletsoang oa polokelo -20°C.
Tokisetso Beha indole (1.17 g, 10 mmol), CTAB (50% mol) le oxalic acid (50% mol) ka har'a 25 ml e nang le molala o le mong o pota-potileng ka tlas'a botlolo, eketsa 5 ml ea metsi a hloekisitsoeng, hlohlelletsa ka ho feletseng metsotso e 5 ebe joale. eketsa tharollo ea aqueous formaldehyde (0.38 g tharollo, 5 mmol formaldehyde) dropwise.Etsa lihora tse 3 ka mocheso oa kamore 'me u khaotse ho arabela.Tharollo ea karabelo e ile ea ntšoa ka 15 ml ea ethyl acetate likarolong tse tharo, 'me karolo ea manyolo e ile ea bokelloa' me ea omisoa ka anhydrous Na2SO4 bakeng sa lihora tse 5.The solvent e ile ea tlosoa tlas'a khatello e fokotsehileng 'me ea tsosolosoa ho tloha motsoako oa methanol le metsi (methanol / H2ChemicalbookO = 10/1) ho fana ka 'mala o mosoeu o tiileng 3,3'-diindolylmethane ka lihlahisoa tsa 85%.Bioactivity3,3'-Diindolylmethane (DIM) ke sehlahisoa se ka sehloohong sa tšilo ea lijo ea indole-3-carbinol, e leng ntho e ka 'nang ea e-ba khahlanong le kankere meroho ea cruciferous.3,3'-Diindolylmethane (DIM) ke mohanyetsi ea matla ea hloekileng oa androgenreceptor (AR) .
Liphuputso tsa in vitro li bontšitse hore DIM ke radioprotector e sebetsang hantle le memigator, e sebetsang ka ho susumetsa likarabo tse kang DDR tse tsamaisoang ke ATM hammoho le pontšo ea ho pholoha ha NF-κB.DIM e ka thibela tlhaselo ea lisele tsa tumor, angiogenesis, ho ata le ho etsa hore apoptosis e be teng ka ho fetola litsela tsa lipontšo. joalo ka AKT, NF-κB le FOXO3.E ka boela ea thibela tlhahiso ea liphatsa tsa lefutso tse hlahisoang ke estrogen le ho baka khatello ea maikutlo ea endoplasmic reticulum.chemicalbookDIM e ka fetola metabolism ea estrogen le ho hanyetsa tšebetso ea estrogen le androgen receptor.Lithuto tsa in vivo li bonts'itse hore DIM e sebetsa khahlano le radiation ea systemic kamora litsamaiso tse ngata.Litekong tsa in vivo, DIM e fane ka tšireletso kapa phokotso ea mahlaseli.Litabeng tse tloaelehileng, DIM e etsa hore ATM e sebetse.diM e ka fuoa litoeba ka ho tlatsoa ka molomo (250 mg/kg) ka bioavailability e phahameng mme ha e na t e matla.
