Lihlahisoa
Dexamethasone
Foromo ea Sebopeho
Ea nama
Ponahalo: phofo e tšoeu
Boima: 1.1283
Sebaka se qhibilihang: 262-264°C
Sebaka se belang: 568.2±50.0°C
Lintlha tsa Polokeho
Sehlopha sa kotsi: Thepa e akaretsang
Kopo
E sebelisoa haholo-holo bakeng sa anti-inflammatory le anti allergic.E loketse lefu la ramatiki le mafu a mang a collagen.
Dexamethasone (DXMS) e qapiloe ka lekhetlo la pele ka 1957 mme e thathamisitsoe ho WHO Essential Medicines Standard List e le e 'ngoe ea meriana ea bohlokoa bakeng sa lits'ebetso tsa mantlha tsa bophelo bo botle ba sechaba.
Ka la 16 Phuptjane 2020, WHO e boletse hore liphetho tsa liteko tsa pele tsa bongaka United Kingdom li bonts'itse hore dexamethasone e ka pholosa bophelo ba bakuli ba nang le pneumonia e matla ea neocoronary, ea fokotsa lefu ka hoo e ka bang karolo ea boraro ea bakuli ba sebelisang li-ventilator le hoo e ka bang karolo ea bohlano ho bakuli ba nang le lefu la tsoekere. oksijene feela.
Dexamethasone ke corticosteroid ea maiketsetso e ka sebelisoang ho phekola maemo a mangata a fapaneng, ho kenyelletsa mafu a ramatiki, maemo a itseng a letlalo, ho kula ho matla, asthma, lefu le sa foleng la matšoafo, laryngitis e lokileng, edema ea boko, mohlomong hammoho le lithibela-mafu ho bakuli ba nang le lefu la tsoekere. lefuba.E na le tekanyo ea bokhachane ea C United States, e hlokang tlhahlobo ea hore katleho ea lithethefatsi e feta litla-morao pele e ka fanoa, le tekanyo ea A Australia, e bontšang hore hangata e sebelisoa ho bakhachane. le hore ha ho na bopaki ba kotsi ea lesea.
Liphello tsa Pharmacological
Dexamethasone, eo hape e tsejoang e le flumethasone, fluprednisolone, le dexamethasone, ke glucocorticoid.Lihlahisoa tsa eona li kenyelletsa hydrocortisone, prednisone, joalo-joalo. Liphello tsa eona tsa meriana ke haholo-holo tse khahlanong le ho ruruha, anti-toxic, anti-allergic le anti-rheumatic, 'me e sebelisoa haholo litsing tsa bongaka.Plasma ea eona ea T1/2 ke metsotso e 190 le thishu T1/2 matsatsi a 3.Tlhōrō e phahameng ea mali ea dexamethasone sodium phosphate kapa dexamethasone acetate e fihla ka hora le lihora tse 8 ka ho latellana ka mor'a ente ea intramuscular.Sekhahla se tlamang protheine ea plasma ea sehlahisoa sena se tlase ho feta sa corticosteroids tse ling.Mosebetsi o khahlanong le ho ruruha oa 0.75 mg o lekana le 5 mg ea prednisolone.Adrenocorticosteroids, anti-inflammatory, anti-allergic le anti-toxic liphello li matla ho feta tsa prednisone, 'me liphello tsa ho boloka sodium le potassium excretion li bobebe haholo.
1. Phello e khahlanong le ho ruruha: E ka fokotsa le ho thibela karabo ea lisele ho ruruha, kahoo e fokotsa ponahalo ea ho ruruha.Li-hormone li thibela ho bokellana ha lisele tsa ho ruruha, ho akarelletsa le macrophages le leukocyte, sebakeng sa ho ruruha le ho thibela phagocytosis, ho lokolloa ha li-enzyme tsa lysosomal, le ho kopanya le ho lokolloa ha baemeli ba lik'hemik'hale tsa ho ruruha.
2. Liphello tsa ho itšireletsa mafung: ho kenyelletsa ho thibela kapa ho thibela likarabo tsa 'mele oa ho itšireletsa mafung, ho lieha ho itšoara hantle, ho fokotsa palo ea T lymphocyte, monocyte, le eosinophils, ho fokotsa matla a tlamang a immunoglobulins ho li-receptor tsa lisele, le ho thibela ho kopanya le ho lokolloa ha interleukins. , ka hona ho fokotsa phetoho ea T lymphocyte ho lymphoblasts le ho fokotsa ho atolosoa ha likarabo tsa mantlha tsa 'mele oa ho itšireletsa mafung.E fokotsa phallo ea li-immune complexes ka lera le ka tlase mme e fokotsa bongata ba likarolo tse tlatselletsang le li-immunoglobulins.
E kenella habonolo pampitšaneng ea GI, ka plasma ea T1/2 ea metsotso e 190 le lisele tsa T1/2 tsa matsatsi a 3.Boemo bo phahameng ba mali bo fihlelleha hora e le 1 le lihora tse 8 ka mor'a ente ea intramuscular ea dexamethasone sodium phosphate kapa dexamethasone acetate, ka ho latellana.Sekhahla se tlamang protheine ea plasma ea sehlahisoa sena se tlase ho feta corticosteroids tse ling, mme ts'ebetso e khahlanong le ho ruruha ea sehlahisoa sena 0.75 mg e lekana le 5 mg ea prednisolone.
